It was as an undergraduate at Cambridge where Dr Harriet Groom's passion for molecular virology first began. Harriet completed her PhD under the supervision of Andrew Lever in the Department of Medicine, understanding the control of HIV gene expression. She then moved to the National Institute of Medical Research (now Francis Crick Institute) in London where she helped to disprove the reported novel retrovirus XMRV’s link to human infection and disease. Harriet then began my work on cellular inhibition of retroviruses, focusing on HIV, before moving back to Cambridge in 2015 as a Henslow Research Fellow at Downing College and an Associate Principal Investigator in the Department of Medicine where she continued work on cellular inhibitors of HIV. In her current fellowship Harriet continues to unpick how the intricate interactions between cells and viruses during infection can dictate host response and help us understand normal cell behaviour using retroviruses, herpesviruses and coronaviruses as model systems.
Harriet is currently a Stanley Elmore Research Fellow at Sidney Sussex College and an associated PI in the Department of Medicine, where she researches the molecular interactions between retroviruses and human cells.
What we call the Milky Way, our Galaxy, has been the focus of myth, story and study in every society with a recorded history for millennia. Understanding its structure defeated Isaac Newton. One hundred years ago it was realized that the Milky Way is just one amongst a Universe of galaxies. With electronics, digital systems, and spacecraft we have learned how to measure the structure and assembly history of the Milky Way Galaxy over its 13 billion year history, even identifying ancient stars from the earliest proto-structures to form. We quantify the formation of the chemical elements over time and their distribution in space. We use dynamics to weigh the unseen. We can calculate the future of the Milky Way until it ends its existence as an isolated Galaxy, merging with Andromeda some 5 billion years from now, and the death of the Sun a few billion years after that. This lecture will tell that story.
Present-day efforts to preserve endangered crop varieties emphasize "safety duplication"—a strategy better known as backup—as an essential step in conservation. Important collections of seeds or other plant genetic materials are copied, in whole or part, and sent to physically distant sites to provide security in the case of local disaster. This talk traces the history of seed banking to understand how, why and with what consequences copying collections came to occupy this central place. The intertwined histories of the central long-term seed storage facility of the United States (opened in 1958) and the international seed conservation system developed in the 1970s reveal how changing conceptions of security, linked to changing economic, political and technological circumstances, transformed both the guiding metaphors and the practices of seed conservation. Seed banking gave way to seed backup: whereas early long-term cold storage facilities vested security in robust infrastructures and the capacities of professional staff, between the 1960s and 1990s, this configuration gave way to one in which security was situated in copies rather than capacities. This history ultimately raises questions about the security promised and achieved through present-day infrastructures for crop genetic resources conservation.