With the Society in its 200th year, our founding aim of ‘keeping alive the spirit of inquiry’ has never felt more important. It’s vital to us that we clearly demonstrate how we continue to support research and communication in the field of sciences – whether it’s reporting on how we fund the scientists of the future, through our travel and research grants, or explaining the aims of the Society to our Fellows and the wider interested community.
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Mathematical Proceedings is one of the few high-quality journals publishing original research papers that cover the whole range of pure and applied mathematics, theoretical physics and statistics.
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The Spirit of Inquiry celebrates the 200th anniversary of the remarkable Cambridge Philosophical Society and brings to life the many remarkable episodes and illustrious figures associated with the Society, including Adam Sedgwick, Mary Somerville, Charles Darwin, and Lawrence Bragg.
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Finding and understanding the nature of the first stars at cosmic dawn is one of the most important and most ambitious goals for modern astrophysics. The first populations of stars produced the first chemical elements heavier than helium and formed the first, small protogalaxies, which then evolved, across the cosmic epoch, into the large and mature galaxies, such as the Milky Way and those in our local neighbour. Equally important and equally challenging is the search, in the early Universe, of the seeds of the first population of black holes, which later evolved in the supermassive black holes at the centre of galaxies, with masses even exceeding a billion times the mass of the Sun. When matter accretes on such supermassive black holes it can become so luminous to vastly outshine the light emitted by all stars in their host galaxy.Since its launch, about two years ago, the James Webb Space Telescope has been revolutionizing this area of research. Its sensitivity in detecting infrared light from the remotest parts of the Universe is orders of magnitude higher than any previous observatory, an historical leap in astronomy and, more broadly, in science. I will presents some of the first, extraordinary discoveries from the Webb telescope, which have resulted in several unexpected findings. I will also discuss the new puzzles and areas of investigation that have been opened by Webb’s observations, how these challenge theoretical models, and the prospects of further progress in the coming years.
The maintenance of oxygen homeostasis is a key physiological challenge, inadequate oxygen (hypoxia) being a major component of most human diseases. The lecture will trace insights into human oxygen homeostasis from the founding work of William Harvey on the circulation of the blood to the molecular elucidation of a system of oxygen sensing that functions to measure oxygen levels in cells and control adaptive responses to hypoxia. The lecture will outline how the oxygen sensitive signal is generated by a set of ‘oxygen splitting’ enzymes that modify a transcription factor (HIF) to signal for its degradation (and hence inactivation). It will attempt to illustrate and rationalise the unexpected in biological discovery and discuss the interface of discovery science with the development of medical therapeutics.
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