Lewis Spurrier-Best works in the Science Centre at the Anglia Ruskin University (ARU), Cambridge Campus and is one of two students to be awarded the new Sedgwick studentship by the Cambridge Philosophical Society. Prior to joining ARU Lewis studied his Master of Research in Cancer Biology and Bachelor of Science in Human Biology at Sheffield Hallam University.
Lewis is studying for his PhD in Dr Havovi Chichger’s lab where his research focuses on identifying new therapeutic targets for patients with acute respiratory distress syndrome (ARDS). ARDS is defined as the acute onset of non-cardiogenic pulmonary oedema, resulting in hypoxaemia. Up to 19% of all intensive care unit admissions worldwide are attributed to ARDS with a mortality rate of up to 40% in critical care patients. There is currently no treatment available for the vasculature permeability thought to be the underlying cause of hypoxemia in ARDS, mechanical ventilation is one of the main treatment options for the disease, however, mechanical ventilation does not treat the underlying cause and can cause further damage to the pulmonary vasculature.
Lewis’s research specifically focuses on how the bitter taste receptor T2R14, regulates the permeability of pulmonary vascular endothelium. T2R14 is a G-Protein Coupled Receptor (GPCR) that is usually located in the oral cavity where it functions as a bitter taste receptor, however, it has recently been demonstrated to be expressed in the lung microvasculature where it has been shown to have a functional role in settings of ARDS. Agonists to T2R14 such as noscapine have been shown to have a barrier disrupting effect in cases of lipopolysaccharide (LPS) induced barrier dysfunction while siRNA knockdown of T2R14 was shown to have a barrier protective effect. Lewis is expanding on this research to study the effects of T2R14 antagonists and their potential barrier protective effects with the ultimate goal of identifying new therapeutic targets to treat the underlying cause of ARDS.
Show All
Volcanoes are hazardous and beautiful manifestations of the dynamic processes that have shaped our planet. Volcanoes impact our environment in numerous ways. Over geological time volcanic activity has resurfaced the Earth and provided life with a terrestrial substrate upon which to proliferate. Volcanic degassing has shaped our secondary atmosphere and as part of the process of plate tectonics, maintained just the right amount of water and carbon dioxide at the surface to produce a stable and equitable climate. Magma in the subsurface in volcanic environments today gives Society geothermal energy. The fluids degassed from magmas in the plumbing systems of volcanoes give rise to hydrothermal ore deposits, the source of much of our copper and other metals, critical to the energy transition. In this lecture I will describe the nature and importance of magma degassing for our atmosphere and oceans, as a source of both pollutants and nutrients, and in the formation of mineral deposits. I will describe my own research in carrying out measurements of volcanic gases (using a range of spectroscopic methods, from the ground and using drones), and analysis of erupted lavas, to understand the chemistry and physics of volcanic outgassing and its role in sustaining our planetary environment.
One of the many outstanding achievements of G I Taylor was the discovery of relatively simple statistical laws that apply to highly complex turbulent flows. The emergence of simple laws from complexity is well known in other branches of physics, for example the emergence of the laws of heat conduction from molecular dynamics. Complexity can also arise at large scales, and the structural vibration of an aircraft or a car can be a surprisingly difficult phenomenon to analyse, partly because millions of degrees of freedom may be involved, and partly because the vibration can be extremely sensitive to small changes or imperfections in the system. In this talk it is shown that the prediction of vibration levels can be much simplified by the derivation and exploitation of emergent laws, analogous to some extent to the heat conduction equations, but with an added statistical aspect, as in turbulent flow. The emergent laws are discussed and their application to the design of aerospace, marine, and automotive structures is described. As an aside it will be shown that the same emergent theory can be applied to a range of problems involving electromagnetic fields.
Registered address:17 Mill LaneCambridgeCB2 1RXUnited Kingdom
Business address:6A King's ParadeCambridgeCB2 1SJUnited Kingdom
Office hours at the business address:Monday and Thursday: 10am-12pm and 2pm-4pm.
Please contact philosoc@group.cam.ac.uk to agree a timing before visiting the office.