Video: Dr Richard Henderson: Using electron microscopy to understand the molecules of life - Honorary Fellows Lecture

Nobel Prize winner in Chemistry Dr Richard Henderson gives our Honorary Fellows Lecture: Using electron microscopy to understand the molecules of life. 

Structural biology has been highly successful during the last 60 years. The first protein structure of sperm whale myoglobin was solved in 1960 using X-ray crystallography, a method now producing over 10,000 structures per year, all of them deposited in and available from the Protein Data Bank (PDB).  In recent years, electron cryomicroscopy (cryoEM) of single particles plunge-frozen in a thin film of amorphous ice, has developed rapidly in power and resolution, so that over 3,000 PDB depositions based on cryoEM were made in the last year.  Many of these cryoEM structures represent unstable, flexible or dynamic assemblies whose structure cannot be determined by any other method, and improvements to the method are being continuously developed.  We are fortunate now to have superbly detailed images of many of the most important molecules of life, with electron microscopy still having great potential to expand its reach.

Dr Richard Henderson CH FRS FMedSci HonFRSC is a Scottish molecular biologist and biophysicist and pioneer in the field of electron microscopy of biological molecules. Henderson shared the Nobel Prize in Chemistry in 2017 with Jacques Dubochet and Joachim Frank.

Share this article:

Themes

Publications

Discover our Journals & Books

From Darwin’s paper on evolution to the development of stem cell research, publications from the Society continue to shape the scientific landscape.

Membership

Join the Cambridge Philosophical Society

Become a Fellow of the Society and enjoy the benefits that membership brings. Membership costs £20 per year.

Join today

Upcoming Events

Show All

30

06

Postponed - Our Quantum Future - One day meeting

Organised by : Professor Ron Horgan and Professor Adrian Kent

  • 09:00 - 18:00 Cambridge University Engineering Department

Please Note: 
This event has been postponed until after Easter 2022. Further details will be announced.

Cambridge University Engineering Department

View Details