Nobel Prize winner in Chemistry Dr Richard Henderson gives our Honorary Fellows Lecture: Using electron microscopy to understand the molecules of life.
Structural biology has been highly successful during the last 60 years. The first protein structure of sperm whale myoglobin was solved in 1960 using X-ray crystallography, a method now producing over 10,000 structures per year, all of them deposited in and available from the Protein Data Bank (PDB). In recent years, electron cryomicroscopy (cryoEM) of single particles plunge-frozen in a thin film of amorphous ice, has developed rapidly in power and resolution, so that over 3,000 PDB depositions based on cryoEM were made in the last year. Many of these cryoEM structures represent unstable, flexible or dynamic assemblies whose structure cannot be determined by any other method, and improvements to the method are being continuously developed. We are fortunate now to have superbly detailed images of many of the most important molecules of life, with electron microscopy still having great potential to expand its reach.
Dr Richard Henderson CH FRS FMedSci HonFRSC is a Scottish molecular biologist and biophysicist and pioneer in the field of electron microscopy of biological molecules. Henderson shared the Nobel Prize in Chemistry in 2017 with Jacques Dubochet and Joachim Frank.
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What we call the Milky Way, our Galaxy, has been the focus of myth, story and study in every society with a recorded history for millennia. Understanding its structure defeated Isaac Newton. One hundred years ago it was realized that the Milky Way is just one amongst a Universe of galaxies. With electronics, digital systems, and spacecraft we have learned how to measure the structure and assembly history of the Milky Way Galaxy over its 13 billion year history, even identifying ancient stars from the earliest proto-structures to form. We quantify the formation of the chemical elements over time and their distribution in space. We use dynamics to weigh the unseen. We can calculate the future of the Milky Way until it ends its existence as an isolated Galaxy, merging with Andromeda some 5 billion years from now, and the death of the Sun a few billion years after that. This lecture will tell that story.
Present-day efforts to preserve endangered crop varieties emphasize "safety duplication"—a strategy better known as backup—as an essential step in conservation. Important collections of seeds or other plant genetic materials are copied, in whole or part, and sent to physically distant sites to provide security in the case of local disaster. This talk traces the history of seed banking to understand how, why and with what consequences copying collections came to occupy this central place. The intertwined histories of the central long-term seed storage facility of the United States (opened in 1958) and the international seed conservation system developed in the 1970s reveal how changing conceptions of security, linked to changing economic, political and technological circumstances, transformed both the guiding metaphors and the practices of seed conservation. Seed banking gave way to seed backup: whereas early long-term cold storage facilities vested security in robust infrastructures and the capacities of professional staff, between the 1960s and 1990s, this configuration gave way to one in which security was situated in copies rather than capacities. This history ultimately raises questions about the security promised and achieved through present-day infrastructures for crop genetic resources conservation.