The sensation of pain is one which nearly everyone is familiar with, usually being considered an unpleasant experience. Wouldn’t a life without pain be better? Drawing on human genetics and the wider animal kingdom, we shall see that there are in fact benefits to pain, or rather nociception, the neural process encoding noxious stimuli. Pain is not however static. For example, following an accident, the injured part of the body becomes more sensitive, a phenomenon that usually resolves as the injury heals. Understanding the molecular processes by which pain functions and how the sensitivity in the system changes under different conditions is important for the development of novel therapeutics to treat the chronic pain, such as that associated with osteoarthritis, inflammatory bowel disease, endometriosis, and a wealth of other conditions. Looking to potential new therapeutic avenues, we will discuss what can be learned from studying human genetics and extremophile organisms, such as the naked mole-rat, as well what the future holds regard gene- and cell-based therapy.
Signals from the beginning of the universe
In the millennium poll, James Clerk Maxwell (1831-1879) was voted the third greatest physicist of all time – behind Newton and Einstein. But Maxwell’s extraordinary range of interests and achievements extended far beyond his well-known equations for electromagnetism and his thermodynamic relations, and this meeting will explore just a few of the fields in which Maxwell did seminal work. The day will begin with an overview of James Clerk Maxwell’s life and achievements. The talks following will highlight some topics in which current research is revealing interesting developments, but also looking back to Maxwell’s insights in laying the foundations for so much of our contemporary science.There will be a small exhibition of artefacts including some of Maxwell’s models from the Cavendish collection.James Clerk Maxwell had strong links with the Cambridge Philosophical Society during his time at Cambridge. He studied mathematics as an undergraduate – initially at Peterhouse, but moving to Trinity before the end of his first term. He graduated in 1854, and shortly afterwards presented his first paper On the transformation of surfaces by bending to the Cambridge Philosophical Society. His career took him to Aberdeen, Edinburgh and King’s College London before returning to Cambridge in 1871 to become the first Professor of Experimental Physics. He was President of the Cambridge Philosophical Society 1875-1877.
09.00
Welcome, introduction
Dr Claire Barlow
09.15
The Unknown Maxwell
Professor Bruce Hunt (University of Texas)
10.00
The Mechanical Origins of Maxwell’s Equations
Professor Malcolm Longair (Cavendish)
10.45-11.00
Introduction to Maxwell artefacts on display in LR4
11.00
Tea/coffee in LR4
11.30
Maxwell and the nature of primary colours
Professor John Mollon (Psychology)
12.15
From Maxwell’s fields to quantised light
Professor Peter Knight
(Imperial College)
13.00-14.00
Lunch in LR4
14.00
Maxwell and the Geometry of Structural Equilibrium
Professor Bill Baker (Cambridge University Honorary Professor of Structural Engineering), Professor Allan McRobie (Engineering)
14.45
Control Systems and the Origin of Cybernetics
Professor Rodolphe Sepulchre (Engineering)
15.30
16.00
Saturn’s rings, gravitational instability and the formation of planets
Professor Gordon Ogilvie (DAMTP)
16.45
Thermodynamics and Maxwell's Demon Demystified
Professor John Ellis (Cavendish)
17.30
Closing remarks
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